Wednesday, November 28, 2007

Cell Position Data

One thing that I'll need before too much longer is position information for the cells in the C. elegans embryo. I did some literature searches, and came up with a couple of papers.

The first, "The embryonic cell lineage of the nematode Caenorhabditis elegans" by Sulston, et al, seems to be the seminal paper on cell lineage, and contains a ton of information on lineage as well as cell position in the embryo.

The second, "Assessing normal embryogenesis in Caenorhabditis elegans using a 4D microscope: variability of development and regional specification" by Schnabel, et al, also contains a fair amount of cell position information. The other thing that makes this paper interesting is that it shows the variability of events during embryogenesis. This variability data will be useful far in the future to help establish a baseline against which various models can be validated.

Last but not least, I found a couple of software packages that provide views of the developing embryo. One, Angler, contains a data file in the unix version that gives the position of each cell in 4D space (3D position plus time of birth).

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